Ctgf target

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August undefined, 2024

WebMay 8, 2024 · Connective tissue growth factor (CTGF) associated with transforming growth factor-β (TGF-β) play a pivotal role in the pathophysiology of many fibrotic disorders. However, it is not clear ... WebIn this review, we comprehensively discuss the expression of CTGF and its regulation, oncogenic role, clinical relevance, targeting strategies, and therapeutic agents. Herein, …

CTGF/CCN2 Products: R&D Systems

WebAug 30, 2024 · CTGF expression is increased in renal fibrosis as well as hepatic fibrosis, and a recent study reported CTGF as a new target in renal fibrosis . In addition, autophagy is essential for the maintenance of kidney homeostasis, structure, and function, and dysregulated autophagy contributes to the pathogenesis of various kidney diseases [ 29 ]. WebApr 1, 2024 · All the observations have illustrated that CTGF could be a potential target in the treatment of hepatic fibrosis. A siRNA called 483 attenuated the expression of extracellular matrix by reducing more than 90% expression of CTGF. It showed a practical function to reverse the activation of HSC and cure hepatic fibrosis 198, 199. Besides, a … maxwell\u0027s shoe store

Inhibition of Connective Tissue Growth Factor Overexpression …

WebMar 23, 2024 · As shown in Figure S3C, overexpression of NFATC2 significantly upregulated the expression levels of the target genes of Hippo/YAP signaling pathway (CTGF and Gli2) 18–20 in both HCT-116 and HT-29 cells. Conversely, reduced mRNA expression levels of CTGF and Gli2 were observed in NFATC2-knockdown HCT-116 … WebMar 18, 2010 · Connective tissue growth factor (CTGF) is a profibrogenic factor that stimulates fibroblast proliferation, cell adhesion, and extracellular matrix production (9,10). The potential role of CTGF in pathological fibrosis has been established , and CTGF has been suggested to be an attractive therapeutic target in some fibrotic diseases . WebSep 6, 2024 · Our previous studies showed that Cx43 was a downstream target protein of CTGF in chondrocytes that regulated cell-to-cell communication [27, 31]. Simultaneously, cementocytes specifically express Cx43 as a gap junction carrier to facilitate intercellular communication . Therefore, we speculated that Cx43 regulated by CTGF was involved in … maxwell\\u0027s shoes new minas

NFATC2 is a novel therapeutic target for colorectal cancer stem cells

WebAug 28, 2024 · In association with positive and negative transcription factors, Smads regulate a wide spectrum of target genes . ... -derived sol-Eng. sol-Eng was detected in lysates of HepG2 cells and its presence reduces the expression of the TGF-β1 target protein CTGF at all-time points analysed. In order to test if sol-Eng can bind ligand, we … WebThe multimodular CTGF has the ability to bind multiple ligands and has numerous effects on development, differentation, and disease. The C-terminal cysteine knot motif contains the HSPG (proteoglycan) and low … maxwell\u0027s sentence reducedWebJul 7, 2008 · National Center for Biotechnology Information maxwell\\u0027s shellfish port republic nj

"WebSep 10, 2024 · Congenital heart disease is one of the leading causes of pediatric morbidity and mortality, thus highlighting the importance of deciphering the molecular mechanisms that control heart development. As the terminal transcriptional effectors of the Hippo–YAP pathway, YAP and TEAD1 form a transcriptional complex that regulates the target gene … " - Ctgf target

Ctgf target

Insights into the impact of hepatitis B virus on hepatic stellate cell ...

WebAntibodies that detect CTGF can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, ELISA and … WebCTGF is a TGF-β target gene that is activated by Smad proteins after TGF-β binds to its receptors. Like TGF-β, CTGF stimulates the deposition of ECM components, including collagen. However, unlike TGF-β, CTGF does not exert any effect on epidermal or inflammatory cells. Thus, CTGF appears to specifically influence ECM deposition at the ...

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WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the … WebOverexpression of CTGF enhances resistance to 5-FU-promoting cell death. To examine the potential role of CTGF on the regulation of chemoresistance to 5-FU, we first confirmed that the pCDNA3.1-CTGF vector and CTGF small interfering RNA (CTGF-siRNA) were overexpressing and interfering with the protein and mRNA of CTGF in HT-29 and SW620 …

WebCTGF is a TGF-β target gene that is activated by Smad proteins after TGF-β binds to its receptors. Like TGF-β, CTGF stimulates the deposition of ECM components, including …

WebMar 9, 2024 · Ctgf is the direct target gene of SOX9 in chondrocytes and nucleus pulposus cells. As shown in mouse model of kidney fibrosis CTGF is significantly involved in fibrosis-associated renal lymphangiogenesis through regulation of, and direct interaction with, VEGF-C. CTGF and BMP2 are induced following myocardial ischemia in mice and humans. WebFeb 11, 2024 · If you need help completing an application, please call Georgia Gateway Help Desk 1-877-423-4746. How will I get my TANF benefits? # __ Upon approval, your …

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WebOct 29, 2024 · CTGF and TGFβ were found to be increased in the alveolar epithelial cells inoculated with SARS-CoV-2 (Xu et al., 2024). As a … herr dispatchesWebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast … herrdraculaWebCTGF is a direct target of YAP and TEAD. (A) Both YAP and TEAD1 bind to the CTGF promoter. ChIP from MCF10A cells was performed with control IgG, YAP, or TEAD1 antibody as indicated. maxwell\u0027s shoes new minasWebFeb 2, 2014 · Here, we define connective tissue growth factor (CTGF) as a therapeutic target for metastatic melanoma. Clinically, CTGF expression correlates with tumor progression and is strongly induced by hypoxia through HIF-1 and HIF-2-dependent mechanisms. Genetic inhibition of CTGF in human melanoma cells is sufficient to … herrdoftWebIncreasing evidence emphasizes the notion that CTGF is pivotal in cancer initiation and progression. The interplay of tumor cells and the tumor microenvironment significantly affects the efficacy of therapeutic agents. The functional importance of CTGF provides an opportunity to disrupt ECM-mediated protection and to target tumors directly. maxwell\\u0027s shoe storeWebAug 9, 2024 · CTGF is not only a mediator of tissue fibrosis but also a potential biological marker and a potential target for the treatment of renal fibrosis. More clinical studies are needed to assess the safety and efficacy of CTGF-neutralizing antibodies in patients with diabetes or non-diabetic kidney disease. herr companyWebFeb 13, 2024 · The downstream target genes of YAP that are of primary interest in this study are Connective Tissue Growth Factor (CTGF) and Cysteine-rich angiogenic protein … maxwell\u0027s siblings