Hif bcl-2

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August undefined, 2024

Web15 de out. de 2013 · Corpus ID: 33732404; Influences of HIF-lα on Bax/Bcl-2 and VEGF expressions in rats with spinal cord injury. @article{Chen2013InfluencesOH, title={Influences of HIF-l$\alpha$ on Bax/Bcl-2 and VEGF expressions in rats with spinal cord injury.}, author={Mao-hua Chen and Qing-Xian Ren and Wenzhe Yang and Xianglin … Web11 de nov. de 2024 · Under hypoxic conditions, the nonadaptive cancer cells undergo apoptosis via HIF-1- and P53-dependent mechanisms. The Bcl-2 family can be divided into two categories: anti-apoptotic proteins such as Bcl-2, Bcl-xl, Myeloid cell leukemia-1 (Mcl-1), and cell death abnormality gene 9 (CED9); and pro-apoptotic proteins including …

The effect of HIF on metabolism and immunity - Nature

Web26 de jul. de 2010 · (A) Western blot analysis of HIF-1α protein expression in M14 control cells (puro) and bcl-2 stably overexpressing (Bcl2/5, Bcl2/37) clones treated with 17-AAG under hypoxia or exposed to normoxia for 24 h. (B) HRE-dependent transcriptional activity in the cells treated with 17-AAG from 0.05 to 2 µM under hypoxia or exposed to normoxia … WebIn addition to act as an antiapoptotic protein, B-cell lymphoma (bcl)-2 can also promote tumor angiogenesis. In this context, we have previously demonstrated that under hypoxia … pay for brown bin collection boston

Hypoxia-induced autophagy reduces radiosensitivity by the HIF …

Web22 de jan. de 2024 · Increased Bcl-2 Protects GCs From Apoptosis During Follicular Development. Bax is a member of the Bcl-2 family, which plays a positive role in … Web目的探讨熊果酸对喉癌Hep-2细胞B淋巴细胞瘤-2(Bcl-2)、凋亡相关因子Bcl-2相关X蛋白(Bax)基因表达及凋亡的影响。方法选取Hep-2喉鳞状细胞癌细胞接种于96孔板中培养,随机分为A、B、C组,每组10个复孔,A组给予常规培养,B组在此基础给予50.0μmol·L(-1)熊果酸,C组给予6μmol·L(-1)熊果酸,C组给予6μmol·L(-1)顺铂。 WebIncreased HIF-1a protein expression and DNA binding activity were detected in bcl-2 overexpressing cells compared with control cells. An enhanced functional activity of … pay for blue badge online lincolnshire

Immunohistological expression of HIF‐1α, GLUT‐1, Bcl‐2 and Ki ...

Hif bcl-2

Hypoxia Inducible Factor (HIF-1a and HIF-2a) Expression …

WebKEGG Orthology (KO) [BR: ko00001] 09120 Genetic Information Processing. 09123 Folding, sorting and degradation. 04141 Protein processing in endoplasmic reticulum. K02161 BCL2; apoptosis regulator Bcl-2. 09130 Environmental Information Processing. 09132 Signal transduction. 04340 Hedgehog signaling pathway. K02161 BCL2; … Web(HIF-1α), Bcl-2, and miR-210 was detected by western blotting and quantitative real-time polymerase chain reaction (PCR). HIF-1α and miR-210 inhibition was induced by siRNA trans-fections. Apoptosis detection and colony assays were performed to determine radiosensitivity. HIF-1α and miR-210 showed a significant increase under hypoxic condition.

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WebStarting at 6 h, the apoptotic index increased in a time-dependent manner, in correlation with the expression of HIF-1alpha, Bcl-2, Bcl-xL, Bax and cleaved-Caspase-9. … Web結構. 缺氧大部分需要氧氣呼吸的物種，都擁有保守序列HIF-1。其轉錄都有嚴格的調控機制。HIF-1是由一個α亞基和一個β亞基組成的異源蛋白二聚體，而β亞基是一種芳香烃受体核转位子（英语： Aryl hydrocarbon receptor nuclear translocator ）（ARNT）。 HIF-1屬於鹼性螺旋-環-螺旋（bHLH）家族中的PER-ARNT-SIM ...

Web27 de jul. de 2010 · The bcl-2-induced HIF-1alpha stabilization in response to low oxygen tension conditions was achieved through the impairment of ubiquitin-dependent HIF … Web16 de abr. de 2024 · Human BCL-2 (amino acids 1–205) was cloned into pET-28a vector with a C-terminal 6×HIS-tag. Human p53 containing the DBD (p53-DBD, amino acids 92–292) was cloned into vector pMAL-c5x.

Web1 de mar. de 2024 · Puerarin alleviated lameness, enhanced angiogenesis and growth performance and serum and antioxidant enzymes, decreased apoptosis and recuperated … Web10 de nov. de 2014 · Under hypoxia, HIF-1α induces miRNA-210 which in turn enhances autophagy and reduces radiosensitivity by downregulating Bcl-2 expression in colon cancer cells. Our results imply that autophagy contributes to the reduction of radiosensitivity in hypoxic environment, and the process is mediated through the HIF-1α/miR-210/Bcl-2 …

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Web15 de out. de 2013 · Hypoxia-inducible factor 1-alpha (HIF-1α) is a subunit of HIF-l and thought to be able to protect hypoxic cells from apoptosis or necrosis under ischemic and … pay for blue badge croydon councilWebPublication Bcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90. Trisciuoglio D, Gabellini C, Desideri M, Ziparo E, Zupi G, Del Bufalo D. Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor that is a critical mediator of the cellular response to hypoxia. pay for blood donations near meWebBcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90. Trisciuoglio D , Gabellini C , Desideri M , Ziparo E , Zupi G , Del … screwfix floating shelvesWebThese molecules primarily downregulate HIF-1α and its downstream target genes causing inhibition of OSCC cell proliferation and induced expression of apoptosis regulatory … pay for bridge crossingWeb18 de jan. de 2024 · The results of Co-IP analysis further found the level of Bcl-2/BNIP3 complex was obviously higher than that of Bcl-2/beclin1 complex in the ovaries of Day 1, whereas reversed on Day 4 or 10 after pregnancy, revealing that Bcl-2 is an effective rheostat to orchestrate the induction or the inhibition of Beclin-1-dependent autophagy by … pay for brown bin collection east hertsWeb17 de abr. de 2024 · p53 acts together with p73 and p63 proteins in tumor suppression 4. In addition to p53, exo-PpIX activates p73 by binding to N-terminal domain and inhibits the p73/MDM2 and p73/MDMX interactions ... pay for brown bin boston lincsWebRAR相关孤儿受体（英語： RAR-related orphan receptor ， RORs ）是核受体的一个家族，是细胞内转录因子的一员 [1] [2] 。. 有三个ROR家族成员： ROR-α 、 -β 和 -γ 分别由基因 RORA 、 RORB 、 RORC 编码。. RORs的不寻常之处在于它们是以单体形式结合到激素 … pay for blue badge