Paeoniflorin solubility

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August undefined, 2024

WebPaeoniflorin is a chemical compound which is one of the major constituents of an herbal medicine derived from Paeonia lactiflora. [1] It can also be isolated from the fresh water … WebPaeoniflorin (PA) is an amorphous glucoside isolated from the aqueous extract of roots of the peony plant (Paeonia lactiflora Pall.) and exerts various pharmacological effects in the nervous system. Methods Male prenatally stressed offspring were used to investigate the antidepression-like effects and possible mechanism of PA.

A review on the pharmacokinetics of paeoniflorin and its anti ...

WebFeb 1, 2024 · Paeoniflorin, a water-soluble monoterpene glucoside, is the major bioactive monomer extracted from the root of Paeonia lactiflora pall. Increasing evidence has suggested that this natural compound might be used to treat various NDDs, and its potential molecular mechanisms are related to the modulation of Ca 2+ /ROS homeostasis in cells. WebMar 2, 2024 · Injection of paeoniflorin at 5 mg/kg and 10 mg/kg significantly increased the exploration of the new route compared to the old route (from 41.68% to 58.32% and from 34.18% to 65.82%, respectively). These results demonstrated that paeoniflorin ameliorated the spatial learning memory deficit induced by LPS. Open in a separate window Figure 1 find files and folders in windows 11

Frontiers Therapeutic potential of paeoniflorin in …

WebPaeoniflorin (NSC 178886,Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall. Paeoniflorin reduces COX-2 expression. Paeoniflorin alleviates … WebBenzoylpaeoniflorin, a natural product isolated from Chinese paeony root, could inhibit COX-1 and COX-2 in vitro. Solubility (25°C) In vitro Chemical Information In vivo Formulation Calculator (Clear solution) Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment) WebPaeoniflorin (Pae) is the most abundant component and the main biologically active ingredient of TGP. Pharmacologically, Pae exhibits powerful anti-inflammatory and … find file manager windows 10

The multifaceted mechanisms of Paeoniflorin in the

Paeoniflorin - Wikipedia

WebApr 11, 2024 · 2008.9-2011.6 承德医学院中药学硕士. 2015.9-2024.6 沈阳药科大学中药学博士. 工作经历. 2011.7-至今承德医学院教师. 主要著作及论文. [1] Liu Pei,Zhou Jian-Yu,Chang Jin-Hua et al. Soluplus-Mediated Diosgenin Amorphous Solid Dispersion with High Solubility and High Stability: Development, Characterization ... WebPaeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall. Target: Others Paeoniflorin (PF) is the principal bioactive component of Radix Paeo- niae alba, which is widely used in Traditional Chinese Medicine for the treatment of neurodegenerative disorders such as Parkinson's disease (PD) [1]. find file in subfolders linuxWebFeb 1, 2024 · Paeoniflorin (PF; C 23 H 28 O 11; Figure 1) is the major bioactive component extracted from the root of Paeonia lactiflora pall. This water-soluble monoterpene glucoside was first isolated in 1963, and its chemical structure was initially determined in 1972 [].Converging lines of evidence have indicated that paeoniflorin has wide-spectrum … find file in shell script

"WebDec 19, 2024 · Paeoniflorin, the main component of total glucosides of paeony (TGP), shows good therapeutic effects in arthritis, but has low bioavailability when administered orally. Avoiding such a deficiency for topical administration would expand its clinical application. This study aimed to avoid these limitations by using nanotechnology … " - Paeoniflorin solubility

Paeoniflorin solubility

A review on the pharmacokinetics of paeoniflorin and its anti ...

WebPaeoniflorin decreases immobility in animals undergoing the forced swim test and tail suspension test and increases levels of 5-HT in the hippocampus. Additionally, … WebOther Name: Chinese White Blossom Extract Powder. Active Ingredient: Total glucosides of Paeonia (TGP): Paeoniflorin, Oxypaeoniflorin, Albiflorin, Benzoylpaeoniflorin. Appearance: Yellowish-brown Powder. Specifications: Paeoniflorin 10%~40% (HPLC), 1.5% Albasides, 80% Glycosides. Solubility: Slightly soluble in water.

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WebSep 2, 2024 · Paeoniflorin (PF), a water-soluble monoterpene glycoside, is extracted from the dried roots of Paeonia lactiflora Pall.. Studies have shown that PF has a wide range of pharmacological effects, such as anti-inflammation [ 12 ], anti-oxidation [ 13 ], anti-depressant [ 14 ], and anti-apoptosis [ 15 ]. WebPaeoniflorin is a chemical compound which is one of the major constituents of an herbal medicine derived from Paeonia lactiflora. [1] It can also be isolated from the fresh water fern Salvinia molesta. [2] In Paeonia, it can form new compounds with addition of phenolic substituents. [3]

WebDec 1, 2012 · Pae is a water-soluble monoterpene with strong hydrophilicity, weak lipophilicity, and weak transmembrane absorption [4, 5]. The low absorption of Pae is related to the intestinal first-pass... WebPaeoniflorin C23H28O11 CID 442534 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ...

WebPaeoniflorin is a water-soluble monoterpenoid glycoside that can be derived from multiple herbaceous plants, such as Radix Paeoniae Rubra, Radix Paeoniae Alba, Paeonia … WebSep 3, 2024 · Pae is a water-soluble monoterpene with strong hydrophilicity, weak lipophilicity, and weak transmembrane absorption [ 4, 5 ]. The low absorption of Pae is related to the intestinal first-pass...

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WebNov 21, 2016 · Paeoniflorin (Pae), a water-soluble monoterpene glucoside, is the main effective component of total glucoside of paeony (TGP). Pae has a very low bioavailability (3.6%). The aim of this study was to investigate the effects of sex, food and disease status on the pharmacokinetics of paeoniflorin-6′-O-benzene sulfonat find file pythonWebPaeoniflorin is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of paeoniflorin in these solvents is approximately 30 mg/ml. … find files by name only on my computerWebPaeoniflorin (PF, C 23 H 28 O 11 , molecular weight: 480.51, oral bioavailability: 53.87%, soluble in water, methanol, ethanol and chloroform) is the main active ingredient of … find file or directory in linuxWebNov 16, 2006 · According to the strong water solubility (>50 mg mL −1) and polarity of paeoniflorin, a mobile phase with lower organic phase proportion was firstly selected. When acetonitrile–water (18:82, v/v) was adopted as the mobile phase, it was found that good separation was achieved between paeoniflorin, picroside II and the endogenous ... find file path macWebOxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects. … find filename bashWebPaeoniflorin has been previously shown to attenuate cognitive damage inflicted by exogenous Aβ protein. Using transgenic Caenorhabditis elegans models expressing human Aβ 1-42 , we demonstrate here that paeoniflorin can delay progressive paralysis caused by endogenous Aβ expression and reduce the amount of toxic Aβ oligomers in vivo ... find files by name linuxWebPaeoniflorin, a water-soluble monoterpene glucoside, is the major bioactive monomer extracted from the root of Paeonia lactiflora pall. Increasing evidence has suggested that this natural compound might be used to treat various NDDs, and its potential molecular mechanisms are related to the modulation of Ca 2+ /ROS homeostasis in cells. In ... find file path python