Webb6 apr. 2024 · Produced mainly by epithelial cells and expressed in the skin, lungs, thymus, and intestinal mucosa, TSLP has two known isoforms, namely, long and short TSLP. [ 19] Short TSLP is the main isoform, which is expressed under steady state and has anti-inflammatory and antimicrobial properties. WebbOverview Abstract Background: Oncostatin M (OSM) may promote type 2 inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP) by inducing thymic stromal lymphopoietin (TSLP). Objective: We sought to study the impact of OSM on TSLP synthesis and release from nasal epithelial cells (NECs).
Short ragweed pollen triggers allergic inflammation through Toll …
Thymic stromal lymphopoietin (TSLP) is a protein belonging to the cytokine family. It is known to play an important role in the maturation of T cell populations through activation of antigen-presenting cells. TSLP is produced mainly by non-hematopoietic cells such as fibroblasts, epithelial cells and different types of … Visa mer TSLP production has been observed in various species, including humans and mice. In humans TSLP is encoded by the TSLP gene. Alternative splicing of this gene results in two transcript variants. Visa mer It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of myeloid (CD11c ) dendritic cells. TSLP has also been shown to activate the maturation of a specific subset of dendritic … Visa mer The TSLP signaling axis is an attractive therapeutic target. Amgen's Tezepelumab, a monoclonal antibody which blocks TSLP, is currently approved for the treatment of severe asthma. Fusion proteins consisting of TSLPR and IL-7Rα which can trap TSLP with excellent affinity … Visa mer • Overview of all the structural information available in the PDB for UniProt: Q969D9 (Thymic stromal lymphopoietin) at the PDBe-KB. Visa mer TSLP expression is linked to many disease states including asthma, inflammatory arthritis, atopic dermatitis, eczema, eosinophilic esophagitis and other allergic states. The factors … Visa mer • Ziegler SF, Liu YJ (July 2006). "Thymic stromal lymphopoietin in normal and pathogenic T cell development and function". Nature Immunology. 7 (7): 709–14. doi:10.1038/ni1360. PMID 16785889. S2CID 26635282. • Liu YJ (August 2007). Visa mer WebbHowever, the underlying mechanism by which pollen induces thymic stromal lymphopoietin (TSLP)-triggered allergic inflammation through epithelial innate immunity … psc computer support officer
Alleviating Skin Barrier Disruption, Skin Inflammation, and Pruritus: …
WebbBiomolecules (Mar 2024) . Association between Serum Levels of Interleukin-25/Thymic Stromal Lymphopoietin and the Risk of Exacerbation of Chronic Obstructive Pulmonary Disease WebbTSLP stands for thymic stromal lymphopoietin. Some facts about TSLP include: It is a cytokine. A cytokine is a glycoprotein that regulates cellular responses. 3 Expressed by … Webb24 juni 2024 · Thymic stromal lymphopoietin (TSLP) was initially demonstrated to be critical in regulating inflammatory responses among various allergic disorders (such as … psc construction authorization